Roads, urbanization, canals, railways, energy corridors and activities of illegal migrants and border security operations not only destroy habitat, but create barriers that isolate wildlife populations and disrupt ecological functions such as gene flow, predator-prey interactions, and migration. Addressing each of these potential barriers one-at-a-time is expensive and inefficient. In each landscape, we must address all these factors concurrently to successfully maintain or restore linkages between habitats and conserve the wildlife and natural ecosystems that Arizona’s residents and visitors rely on and benefit from.